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Pathogens can spread epidemically through populations. Beneficial contagions, such as viruses that enhance host survival or technological innovations that improve quality of life, also have the potential to spread epidemically. How do the dynamics

Despite the powerful nature of the aza-Michael reaction for generating C–N linkages and bioactive moieties, the bis-Michael addition of 1° amines remains ineffective for the synthesis of functional, step-growth polymers due to the drastic reduction

A phosphatidylcholine-based cerasome (PC-cerasome) was prepared by a combination of a copper-catalyzed azide alkyne cyclo-addition (CuAAC) reaction and a sol–gel condensation process. In a 2 wt % urea aqueous solution, azide precursors containing a

Recent evidence has determined that the conserved X chromosome mega-structures controlled by the Firre and Dxz4 loci are not required for X chromosome inactivation (XCI) in cell lines. Here, we examined the in vivo contribution

Protein Kinases (PKs) are allosteric enzymes that play an essential role in signal transduction by regulating a variety of key cellular processes. Most PKs suffer con- formational rearrangements upon phosphorylation that strongly enhance the

Background: Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy and fibrosis. Studies in 2 mouse models (R92W-TnT/R403Q-MyHC) at early HCM stage revealed upregulation of endothelin (ET1) signaling in both mutants, but TGFβ

Neither allograft nor commercially available bone graft substitutes provide the same quality of bone healing as autograft. Incorporation of bioactive molecules like PTH within bone graft substitute materials may provide similar, if not better

RNA has been classically known to play central roles in biology, including maintaining telomeres1, protein synthesis2, and in sex chromosome compensation in certain species3,4. At the center of these important biological systems are noncoding RNAs.

Our group focuses on the development of biomaterial matrices that can serve as advanced culture systems or in vivo delivery systems for primary cells. We exploit material chemistry as a tool to decipher how cells process signals from the

A new discovery provides rare evidence of symbolic behavior in Neanderthal communities and extends the record further geographically and temporally across Europe. Rodríguez-Hidalgo et al. analyzed recently unearthed Spanish imperial eagle