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**The 2018 deadline for this opportunity has passed or the internal application slot has been granted. Updated information will be posted when the next funding cycle opens.**

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Program Summary听

This FOA solicits applications for the Basic research program of the听). The companion FOA,听, solicits applications to the Clinical research program of the ACE. The goal of the ACE is to conduct insightful analyses of human immunology as it applies to autoimmune disease(s) within and among collaborative Centers and especially in the context of Clinical Projects, i.e., clinical trials with integrated mechanistic studies. The members of the Basic and Clinical ACE will work together after award to design, develop, and conduct studies of autoimmunity and autoimmune diseases in humans. This approach is expected to advance our fundamental understanding of human autoimmunity, identify common and distinct mechanisms in the pathogenesis of autoimmune diseases, and clarify mechanisms of action of immune-modulating agents used in therapy or tested in clinical trials.

Deadlines

Internal Expression of Interest Deadline: 11:59pm MST April 4, 2018

NIH Letter of Intent Deadline: May 22, 2018

Full Application Deadline: 5:00pm MST June 22, 2018

Eligibility

An individual may serve as the PI on an application to either this Basic ACE program or the companion , but not both.

Limited Submission Guidelines

Only one application per institution is allowed.

The NIH will not accept duplicate or highly overlapping applications under review at the same time.

Award Information and Duration

NIAID anticipates 3-5 awards.

Application budgets are limited to $675,000 in direct costs per year which includes up to $150,000 annual direct costs each for the Principal and Collaborative Projects, up to $75,000 annual direct costs for Pilot Projects, up to $50,000 annual direct costs for the Administrative Core, and up to $250,000 in annual direct costs for the ACE Funds Management Core.

The scope of the proposed project should determine project period. The maximum project period is 5 years.