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hPOT1-ssDNA Complex
Selected Publications

  • Lim, C. J., Barbour, A. T., Zaug, A. J., Goodrich, K. J., McKay, A. E., Wuttke, D. S., & Cech, T. R. The structure of human CST reveals a decameric assembly bound to telomeric DNA. Science, 368, 1081-1085 (2020).

  • Youmans, D.T., Gooding, A.R., Dowell, R.D., Cech, T.R. Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. Mol Cell, 81, 488-501 (2021).

  • Zaug, A. J., Goodrich, K. J., Song, J. J., Sullivan, A. E. & Cech, T. R. Reconstitution of a telomeric replicon organized by CST. Nature, 608, 819-825 (2022).

  • Song, J., Gooding, A. R., Hemphill, W. O., Love, B. D., Robertson, A., Yao, L., Zon, L. I., North, T. E., Kasinath, V., & Cech, T. R.  Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science, 381, 1331-1337 (2023).

  • Jansson-Fritzberg, L. I., Sousa, C. I., Smallegan, M. J., Song, J. J., Gooding, A. R., Kasinath, V., Rinn, J. L., & Cech, T. R. DNMT1 inhibition by pUG-fold quadruplex RNA. RNA, 29, 346–360 (2023).

  • Hemphill, W. O., Voong, C. K., Fenske, R., Goodrich, J. A., & Cech, T. R.  Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search. Proc Natl Acad Sci U S A, 120, e2220537120 (2023).

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Telomerase