Commentaries /lab/aaron-whiteley/ en Commentary: Phages gain the upper hand in the metabolic arms race for NAD+ /lab/aaron-whiteley/2024/12/05/commentary-phages-gain-upper-hand-metabolic-arms-race-nad Commentary: Phages gain the upper hand in the metabolic arms race for NAD+ Aaron Whiteley Thu, 12/05/2024 - 09:00 Commentaries Nathan Bullen ,  Aaron Whiteley

Molecular Cell (2024). PubMed PMID: .

Abstract

Bacteria often defend against phage infection by deploying NADase effectors to degrade cellular NAD+, thereby halting both bacterial growth and phage replication. In a recent article in Nature, Osterman et al.1 identify phage-encoded counterdefense pathways that reconstitute NAD+ during infection, enabling phages to combat multiple unrelated antiphage systems.

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Citation

Bullen NP, Whiteley AT. Mol Cell. 2024 Dec 5;84(23):4480-4482. doi: 10.1016/j.molcel.2024.11.017. PubMed PMID: 39642854.

Bullen NP, ➤Whiteley AT | Molecular Cell 2024

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Traditional 0 On White ]]> Thu, 05 Dec 2024 16:00:00 +0000 Aaron Whiteley 195 at /lab/aaron-whiteley Commentary: The linguistics of bacterial conflict systems reveal ancient origins of eukaryotic innate immunity /lab/aaron-whiteley/2020/11/19/linguistics-bacterial-conflict-systems-reveal-ancient-origins-eukaryotic-innate-immunity Commentary: The linguistics of bacterial conflict systems reveal ancient origins of eukaryotic innate immunity Anonymous (not verified) Thu, 11/19/2020 - 08:00 Commentaries CBASS antiphage immunity STING bacteriophage immunity Emily Kibby ,  Aaron Whiteley

Journal of Bacteriology (2020) PubMed PMID: 32958633; PubMed Central PMCID: .

Abstract

The arms-race between bacteria and their competitors has produced an astounding variety of conflict systems that are shared via horizontal gene transfer across bacterial populations. In this issue of Journal of Bacteriology, Burroughs and Aravind investigate how these biological conflict systems have been mixed-and-matched into new configurations, often with novel protein domains. The authors additionally characterize the evolutionary history of genes in eukaryotes that appear to have been acquired from these prokaryotic defense systems.

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Kibby EM, Whiteley AT. J Bacteriol. 2020 Nov 19;202(24). doi: 10.1128/JB.00507-20. Print 2020 Nov 19. PubMed PMID: 32958633; PubMed Central PMCID: PMC7685558.

Kibby EM, ➤Whiteley AT. | J. Bacteriology 2020

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Traditional 0 On White ]]> Thu, 19 Nov 2020 15:00:00 +0000 Anonymous 125 at /lab/aaron-whiteley