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Education

PhD, University of Pennsylvania, Bioengineering (2015)

BS, University of Wisconsin-Madison, Chemical and Biological Engineering (2009)

Awards

• NIGMS Maximizing Investigators’ Research Award��
• AB Nexus Collaborative Research Award (2021)
• RIO Seed Grant Award (2021)
• NIGMS T32 Training Grant in Hematology
• NSF Graduate Research Fellowship
• Merck Corporation Scholar in Undergraduate Research

Recent Selected Publications

• Richardson IM, Calo CJ, Hind LE. “Microphysiological Systems for Studying Cellular Crosstalk During the Neutrophil Response to Infection,” Frontiers in Immunology, 2021 Apr 27;12:661537.��
• Hind LE, Giese MA, Schoen TJ, Keller NP, Beebe DJ, Huttenlocher A. “Immune Cell Paracrine Signaling Drives the Neutrophil Response to A. fumigatus in an Infection-on-a-Chip Model,” Cellular and Molecular Bioengineering, 2020 Oct 13;14(2):133-145.��
• McMinn PH, Hind LE, Huttenlocher A, Beebe DJ. “Neutrophil trafficking on-a-chip: an in vitro, organotypic model for investigating neutrophil priming, extravasation, and migration with spatiotemporal control,” Lab Chip, 2019 Nov 7;19(21):3697-3705.��
• Giese MA*, Hind LE*, Huttenlocher A. “Neutrophil plasticity in the tumor microenvironment,” Blood, 2019 May 16; 133(20):2159-2167. *These authors contributed equally.
• Hind LE and Huttenlocher A. “Neutrophil Reverse Migration and a Chemokinetic Resolution,” Developmental Cell, 2018 Nov 19; 47(4):404-405.
• Hind LE, Ingram PN, Beebe DJ, Huttenlocher A. “Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P. aeruginosa,” Blood, 2018 Oct 25;132(17):1818-1828.
• Ingram PN, Hind LE, Jiminez-Torres JA, Huttenlocher A, Beebe DJ. An Accessible Organotypic Microvessel Model using iPSC-Derived Endothelium. Advanced Healthcare Materials. 2018 Jan;7(2).
• Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. “Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues,” Cell Reports. 2017 May 23; 19(8): 1572-1585.
• Hind LE, Lurier EB, Dembo M, Spiller KL, Hammer DA. “Effect of M1-M2 Polarization on the Motility and Traction Stresses of Primary Human Macrophages,” Cellular and molecular bioengineering. 2016 September; 9(3):455-465.
• Hind LE, Vincent WJ, Huttenlocher A. “Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration,” Developmental Cell. 2016 Jul 25;38(2):161-9.
• Yamahashi Y*, Cavnar PJ*, Hind LE*, Berthier E, Bennin DA, Beebe D, Huttenlocher A. “Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D,” Biomedical Microdevices. 2015 Oct;17(5):100. *These authors contributed equally.
• Hind LE, Dembo M, Hammer DA, “Macrophage motility is driven by frontal-towing with a force magnitude dependent on substrate stiffness,” Integrative Biology, 2015 Apr; 7(4):447-453.
• Hind LE, MacKay JL, Cox D, Hammer, DA, “Two-dimensional motility of a macrophage cell line on microcontact-printed fibronectin,” Cytoskeleton, 2014 Sep; 71(9):542-554.

Research Interests

Antimicrobial-resistance is a growing global health concern with deaths from antimicrobial-resistant infections predicted to outnumber cancer deaths by the year 2050. Our group postulates that, in addition to understanding the evolution of antimicrobial resistance and developing new antimicrobial drugs, controlling innate immune cell function could be an effective way to combat infection. However, to precisely control cell function, we first need a better understanding of the signals that drive the innate immune response to infection.

Our group works at the intersection of engineering and immunology to design microfluidic models of the infectious microenvironment inspired by in vivo biology. We then use these models to investigate how multicellular interactions, the physical environment, and soluble signals drive immune cell recruitment to an infection. This work is carried out with the goal of discovering new targets to control immune cell recruitment, resolution, and anti-microbial function.

Other Program Associations

Biomedical Engineering Program

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