Meet the faculty: C. Wyatt Shields IV

C. Wyatt听Shields IV

  • Assistant Professor
  • CHEMICAL AND BIOLOGICAL ENGINEERING
  • BIOMEDICAL ENGINEERING PROGRAM
  • MATERIALS SCIENCE AND ENGINEERING PROGRAM
Address

Office: JSCBB D218

Education

PhD, Duke University, Biomedical Engineering (2016)
BS, University of Virginia, Biomedical Engineering (2011)

Awards

  • Camille Dreyfus Teacher-Scholar Award (2024)
  • Emerging Investigator,听Nanoscale听(2024)
  • Outstanding Junior Faculty Award, Department of Chemical and Biological Engineering (2023)
  • Frontiers of Engineering Participant, National Academy of Engineering (2023)
  • Packard Foundation Fellowship in Science and Engineering (2022)
  • NIH Maximizing Investigators' Research Award (MIRA) (2022)
  • Pew Biomedical Scholar (2022)
  • ONR Young Investigator Program Award (2022)
  • NSF CAREER Award (2022)
  • Beckman Young Investigator Award Finalist (2021)
  • Best On-Demand Talk from the Controlled Release Society (2020)
  • Dean鈥檚 Award for Excellence in Mentoring, Duke University (2016)
  • Exceptional Student Award, ISAC at CYTO (2015)
  • NSF Graduate Research Opportunities Worldwide听(2014)
  • Exceptional Student Award,听ISAC at CYTO (2013)
  • NSF Graduate Research Fellowship (2012)

Selected Publications

  • Thome, CP; Fowle, JP; McDonnell, P; Zultak, J; Jayaram, K; Neumann, AK; L贸pez, GP;听Shields IV, CW. 鈥淎coustic pipette and biofunctional elastomeric microparticle system for rapid picomolar-level biomolecule detection in whole blood鈥 Science Advances听2024. 10(42): eado9018. DOI: .
  • Rhodes, ER;* Day, NB;* Aldrich, EC; Shields IV, CW; Sprenger, KG. 鈥淓lucidating the role of carrier proteins in cytokine stabilization within double emulsion-based polymeric nanoparticles鈥 Bioengineering & Translational Medicine2024 (in press). e10722. DOI: .
  • Ausec, TR; Carr, LL; Alina, TB; Day, NB; Goodwin, AP; Shields IV, CW.听鈥淐ombination of chemical and mechanical tumor immunomodulation using cavitating mesoporous silica nanoparticles鈥 ACS听Applied Nano Materials 2024. 7(16): 19109鈥19117. DOI: .
  • Harrell, AG; Thom, SR; Shields IV, CW. 鈥淒issolved gases from pressure changes in the lungs elicit an immune response in human peripheral blood鈥 Bioengineering & Translational Medicine2024. 9(5): e10657. DOI: .
  • Day, NB; Orear, CR; Velazquez-Albino, A; Good,听HJ; Melnyk, A; Rinaldi-Ramos, C; Shields IV, CW. 鈥淢agnetic cellular backpacks for spatial targeting, imaging, and immunotherapy鈥 ACS听Applied Bio Materials 2024. 7(8) 4843鈥4855. DOI: .
  • Lee, JG;* Thome, CP;* Cruse, ZA; Ganguly, A; Gupta, A; Shields听IV, CW. 鈥淢agnetically locked Janus particle clusters with orientation-dependent motion in AC electric fields鈥 Nanoscale 2023. 40(15): 16268鈥16276. (*co-first authors). DOI: .
  • Lee, JG;* Raj, RR;* Day, NB;* Shields IV, CW. 鈥淢icrorobots for biomedicine: Unsolved challenges and opportunities for translation鈥 ACS Nano 2023. 17(15): 14196鈥14204. (*co-first authors). DOI: .
  • Lee, JG; Raj, RR; Thome, CP; Day, NB; Martinez, P; Bottenus, N; Gupta, A; Shields听IV, CW. 鈥淏ubble-based microrobots with rapid circular motions for epithelial pinning and drug delivery鈥 Small 2023. 19(32): 2300409. DOI: .
  • Thome, CP; Hoertdoerfer, WS; Bendorf, J; Lee, JG; Shields IV, CW. 鈥淓lectrokinetic active particles听for motion-based biomolecule detection鈥 Nano Letters 2023. 23(6): 2379鈥2387. DOI: .
  • Day, NB; Dalhuisen, R; Loomis, NE; Adzema, SG; Prakash, J; Shields IV, CW. 鈥淭issue-adhesive hydrogel for multimodal drug release to immune cells in skin鈥 Acta Biomaterialia 2022. 150: 211鈥220. DOI: .

Research Interests

Drug Delivery, Biosensing,听Active Matter,听Soft Materials, Colloid and Interface Science, Microfluidics

Our group is broadly interested in biosensing and drug delivery. The distinguishing approach we take is through engineering particle systems, especially those that interface with biology and controllably respond to external stimuli.听We work听at the intersection of materials, soft matter physics and bioengineering to rationally design colloidal and supracolloidal particles for a range of applications.听We take inspiration from nature, which efficiently assembles matter across length scales that encode a rich variety of behaviors when stimulated by energy.听We have three guiding objectives, to: 1) understand how particles interact in and out of equilibrium and, in turn, how to control their behaviors by tailoring their nano and microscale properties such as shape, size and composition; 2) apply new insights to create collections of "smart" particles that perform useful tasks such as actuate and release encapsulated payloads; and 3) integrate our pipeline of new materials听to advance biosensing and drug delivery by developing new diagnostic and therapeutic platforms for a variety of indications.听

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