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Photo caption: Optical image of living microlenses. Engineered microbes focus light that pass through a thin layer of glass that forms on their surface.  Courtesy of Lynn Sidor, Meyer Lab, University of Rochester.

CU �鶹ӰԺ’s   played a key role in studying tiny bioglass lenses that were designed to form on the surface of engineered microbes, a scientific breakthrough that could pave the way for groundbreaking imaging technologies in both medical and commercial applications.

The project, led by the University of Rochester and published in Proceedings of the National Academy of Sciences, was inspired by the enzymes secreted by sea sponges that help them grow glass-like silica shells. The shells are lightweight, durable and enable the sea sponges to thrive in harsh marine environments.

“By engineering microbes to display these same enzymes, our collaborators were able to form glass on the cell surface, which turned the cells into living microlenses,” said Wil Srubar, a coauthor of the paper and professor of Civil, Environmental and Architectural Engineering and the Materials Science and Engineering Program. “This is a terrific example of how learning and applying nature’s design principles can enable the production of advanced materials.”

Professor Wil Srubar

Using imaging and X-ray techniques, CU �鶹ӰԺ researchers analyzed the silica, also known as “bioglass,” and quantified the amount surrounding different bacterial strains. The CU �鶹ӰԺ researchers demonstrated that bacteria engineered to form bioglass spheres contained significantly higher silica levels than non-engineered strains. Combined with optics data, the results confirmed that bacteria could be bioengineered to create bioglass microlenses with excellent light-focusing properties.

Microlenses are very small lenses that are only a few micrometers in size—about the size of a single human cell and designed to capture and focus or manipulate light into intense beams at a microscopic scale.  Because of their small size, microlenses are typically difficult to create, requiring complex, expensive machinery and extreme temperatures or pressures to shape them accurately and achieve the desired optical effects.

The small size of the bacterial microlenses makes them ideal for creating high-resolution image sensors, particularly biomedical imaging, allowing sharper visualization of subcellular features like protein complexes. In materials science, these microlenses can capture detailed images of nanoscale materials and structures. In diagnostics, they provide clearer imaging of microscopic pathogens like viruses and bacteria, leading to more accurate identification and analysis.

The University of Rochester contributed to this report.