RNA Worlds Conference
The BioFrontiers Institute hosted a very special conference听The听RNA听Worlds: Past, Present and Future,听May 21 to 24, 2023听at Butcher Auditorium in the Jennie Smoly Caruthers Biotechnology Building.听Videos of the talks are now available on the . In addition听there was a Public Forum,听The Future and Ethics of Genome Editing,听May 23rd, 6 鈥 7:30 PM, in Macky Auditorium.
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Organizing Committee
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CU 麻豆影院
University College
Cork
UC Berkeley
MRC, Cambridge
UK
Yale
University of Chicago
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Additional confirmed participants
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Brenda Bass (U of Utah)
Donna Blackmond (Scripps Inst, La Jolla)
Ron Breaker (Yale)
Howard Chang (Stanford)
Jason Chin (MRC Cambridge UK)
Elena Conti (Max Planck Martinsried)
Rhiju Das (Stanford)
Phil Felgner (UC Irvine)
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Ryan Flynn (Harvard Medical School)
Larry Gold (Somalogic)
Rachel Green (Johns Hopkins)
Eckhard Jankowsky (Moderna)
Tracy Johnson (UCLA)
Jerry Joyce (Salk Institute)
Adrian Krainer (CSHL)
Reinhard L眉hrmann (Max Planck G枚ttingen)
Kelly Nguyen (MRC Cambridge)
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Harry Noller (UCSC)
Eric Olson (UTSW)
Roy Parker (CU 麻豆影院)
Jody Puglisi (Stanford)
Phil Sharp (MIT)
John Sutherland (MRC, LMB, Cambridge UK)
脰zlem T眉reci (BioNTech)
Ruixue Wan (Westlake University, Hangzhou China)
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Registration
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Registration for the scientific sessions is now full, but additional participants are invited to watch a live stream in the overflow room, watch the recorded version after the conference, and attend the free Public Forum. There is not a live remote participation option. For questions, contact us.
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PDB 2OEU 鈥 Hammerhead Ribozyme
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Morning
Mike Yarus,听麻豆影院, professor emeritus
Morning Session 1 Chair
9:00 鈥 9:10
Tom Cech
Welcoming听Remarks
9:10 鈥 9:40
Jerry Joyce (Salk Inst)
"Recreating RNA-Based Life"
9:40 鈥 10:10
John Sutherland (MRC, LMB, Cambridge UK)
"Geochemically Plausible Synthesis of Nucleotides"
10:10 鈥 10:40
Donna Blackmond (Scripps Inst, La Jolla)
"Physical and Chemical Models for the Origin of Biological Homochirality"
Break听听
Rob Batey, 麻豆影院
Morning Session 2 Chair
11:00 鈥 11:30
Ron Breaker (Yale)
"Biological and Biochemical Functions of OLE, a Large Bacterial Noncoding RNA"
11:30 鈥 12:00
Harry Noller (UCSC)
"Emergence of the Ribosome from an RNA World"
12:00 鈥 12:30
Tom Cech (CU 麻豆影院)
"From Ribozymes to Epigenetics"
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Afternoon
12:30 鈥 2:00pm
Lunch provided for all registered attendees
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John Atkins, University College, Cork
Afternoon Session Chair and Panel Moderator
2:00 鈥 2:30pm
Jack Szostak (U of Chicago)
"Why Did Biology Begin with RNA and Not Some Other Genetic Polymer?"
2:30 鈥 4:00pm
Panel: Origins of Life 鈥 Will We Ever Know?
Jack, Jerry, John, Donna听and Harry
4:00 鈥 6:00pm
Poster session #1
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PDB 1GID 鈥 Group I Ribozyme
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Morning
John Abelson,听Caltech, professor emeritus
Morning Session 1 Chair
9:10 鈥撎9:40am
Annsea Park听(representing Joan Steitz) (Yale University)
"More Functions for Non-Coding RNAs: Update on the DoG Story"
9:40 鈥撎10:10am
Reinhard L眉hrmann (Max Planck G枚ttingen)
"The Cascade of snRNP Remodeling Steps Leading to the Formation of the Spliceosome鈥檚 Active Site"
10:10 鈥撎10:40am
Ruixue Wan (Westlake University, Hangzhou China)
"Beyond the Major Splicing Pathway: Structural Mechanism of U12-type Splicing by the Minor Spliceosome"
Break听听
Tracy Johnson, UCLA
Morning Session 2 Chair
11:00 鈥撎11:30am
Brenda Bass (Utah)
"Divergent Roles of Dicer鈥檚 Helicase Domain in Antiviral Defense"
11:30 鈥撎12:00pm
Kelly Nguyen (MRC Cambridge)
"Replenishing the Ends: Visualisation of Human Telomerase Holoenzyme by Cryo-EM"
12:00 鈥撎12:30pm
Elena Conti (Max Planck Martinsried)
"Molecular Principles in the Architecture of Nuclear mRNPs"
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Afternoon
12:30 鈥 2:30pm
Lunch provided for all registered attendees
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Olke Uhlenbeck,听麻豆影院, professor emeritus
Afternoon Session Chair
2:30 鈥 3:00pm
Jody Puglisi (Stanford U)
"The Choreography of Translation"
3:00 鈥 3:30pm
Rachel Green (Johns Hopkins)
"Colliding Ribosomes Function as a Signal for Activating Cellular Stress Response Pathways"
3:30 鈥 4:00pm
John Atkins (Cork)
"Decoding Versatility and its Implications"
4:00 鈥 6:00pm
Poster session #2
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PDB 6AI6 鈥 CRISPR sgRNA + target DNA
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Morning
Jerry Joyce, Salk Institute
Morning Session 1 Chair
9:10 鈥 9:40am
Eckhard Jankowsky (Moderna)
"mRNA Medicines"
9:40 鈥 10:10am
脰zlem T眉reci (BioNTech)
"mRNA-Based Immunotherapies"
10:10 鈥 10:40am
Phil Felgner (UC Irvine)
"mRNA Lipid Nanoparticles: Past, Present & Future"
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Jim Dahlberg, University of Wisconsin Madison, professor emeritus
Morning Session 2 Chair
11:00 鈥 11:30am
Phil Sharp (MIT)
"RNA Biology to Therapeutics: An Emerging Story"
11:30 鈥 12:00pm
Howard Chang (Stanford)
"RNA Origin of Sex Biased Immunity"
12:00 鈥 12:30pm
Eric Olson (UTSW)
"CRISPR Correction of Heart and Muscle Disease"
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Afternoon
12:30 鈥 2:00pm
Lunch provided for all registered attendees
2:00 鈥 5:00pm
Free Time
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EMD 21026 鈥 RNA nanocage
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Morning
Brenda Bass, University of Utah
Morning Session 1 Chair
9:10 鈥 9:40am
Adrian Krainer (CSHL)
鈥淎ntisense Therapy for Diffuse Midline Glioma鈥
9:40 鈥 10:10am
Roy Parker (CU 麻豆影院)
"RNP Granules in Health, Viral Infection, and Neurodegenerative Disease"
10:10 鈥 10:40am
Jason Chin (MRC Cambridge UK)
"Reprogramming the Genetic Code"
Break听听
Eckhard Jankowsky, Moderna
Session Chair and Panel Moderator
11:00 鈥 11:30am
Ryan Flynn (Harvard Med School)
"(glyco)RNA Biology on the Cell Surface"
11:30 鈥 12:00pm
Rhiju Das (Stanford U)
"Progress in 3D RNA Modeling"
12:00 鈥 1:00pm
Panel:听The Future of RNA Research and Medicine
Larry Gold, Roy Parker, Phil Sharp, 脰zlem T眉reci
1:00 鈥 1:05pm
Tom Cech
Closing Remarks
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Afternoon
1:00pm
Meeting adjourned
Box lunches provided听for all registered attendees
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Panel Moderator - Tom Cech (麻豆影院)
Keynote Speaker 鈥 Jennifer Doudna (UC Berkeley)
"The World of CRISPR: RNA-Guided Immunity and Genome Editing"
Panelists 鈥 Eric Olson (UTSW), Jason Chin (MRC Cambridge UK), Tracy Johnson (UCLA), 脰zlem T眉reci (BioNTech)
Macky Auditorium
May 23, 6:00鈥7:30听pm
Doors open at 5:30 pm
Public welcome
Registration free but required
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麻豆影院 Activities
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Near the hotel
Get a drink and/or enjoy live music听in the hotel at听听(hotel lobby level),听听(1 block south of hotel on 13th听St; ), or听听(14th听and Pearl St; )
Enjoy a coffee听at听听(Broadway & Spruce St - ), Brewing Market Coffee and Tea (13th听St & Lawry Ln - ), or Trident Booksellers and Cafe虂 (Pearl St between 9th听& 10th听Sts - )
Shop, dine, stroll听on听听pedestrian mall (1 block south of hotel on 13th听St, then running west-east - ).
Take a walk听through the historic Mapleton Hill neighborhood, 麻豆影院鈥檚 largest designated听historic district (). Directly west of the hotel.
Hike 听for great views over 麻豆影院.听Note that it is strenuous, steep, and can be muddy and/or icy听in the winter if there has been recent snow. Typically takes ~2h to complete.
Near campus
Walk along the听. This multi-use path is adjacent to both main and East campuses and follows 麻豆影院 Creek from the mouth of 麻豆影院 Canyon through downtown and to the east part of 麻豆影院.
Hike in听听and the Flatirons (can be walked to from main campus by following Baseline Ave). There are many trails of varying degrees of difficulty originating here as well as a historic dining hall, auditorium, cottages, and lawn/picnic area.
Explore main campus with a听. Coffee available in many buildings, including ATLAS, the Engineering Center, Norlin Library, the University Memorial Center, and Center for Community (C4C).