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Spatiotemporal Dynamics of Neocortical Seizure Activity

Seizures are defined as sudden,Ìýabnormal electrical disturbances in the brain. Patients diagnosedÌýwith epilepsy have chronic, recurrentÌýseizures and often require clinical intervention to prevent these episodes.ÌýUnfortunately, a large portion of epilepsy patients do not respond to current treatment options, in part due to a lack of understanding on how seizures develop in the brain. This talk will discuss some of the complex dynamics associated with seizure activityÌýand how these dynamics can educate epilepsy treatment. Using a combination ofÌý human electrical recordings,Ìýbiological experiments and computational modeling, we have studied the dynamics of seizures at various spatial scales, ranging from a single neuron up to large neuronalÌýnetworks (cm-scale). We have analyzed the interactions between the neurons that produce the seizure and the surrounding tissue and investigated how these interactions can define a seizure'sÌýtrajectory. Finally, we have identifiedÌýelectrical markers that are representativeÌýof these dynamics and could be applied to clinical treatment.Ìý